Well, the Bible explicitly equates disability with "sin" so naturally it would make churchgoers "uncomfortable". And I've seen cases - fictional and IRL - where mental disabilities are considered frightening to children; though I don't agree, I can at least understand, because anything outside behavioural norms is more difficult for youngsters to understand.

But this? This woman is presenting children's TV. That it's on the BBC tells me a lot about her personality without me even having to look up her show: she'll be very perky, very friendly and outgoing. She's just missing a hand. I would understand if it made some people "uncomfortable", but "scary" (and to children) - yeah, that's new.